A&E follows the lives of the doctors and staffs of A&E department in the fictional Mount Sophia Hospital (MSH), showcasing their emotion in the drama surrounding the trauma center and their personal lives. A&E mengikuti perkembangan para doktor dan staff jabatan A&E Hospital Mount Sophia, memaparkan emosi mereka dalam menghadapi drama di pusat trauma dan juga dalam kehidupan mereka sendiri.
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